期刊
NATURE BIOTECHNOLOGY
卷 25, 期 3, 页码 317-318出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nbt1287
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资金
- NCI NIH HHS [R01CA115767, P01CA80124, R01CA96915, P01 CA080124] Funding Source: Medline
- NCRR NIH HHS [P20RR018789] Funding Source: Medline
- NIDDK NIH HHS [K01DK064696] Funding Source: Medline
We describe the differentiation of human embryonic stem (hES) cells into endothelial cells using a scalable two-dimensional method that avoids an embryoid-body intermediate. After transplantation into severe combined immunodeficient (SCID) mice, the differentiated cells contributed to arborized blood vessels that integrated into the host circulatory system and served as blood conduits for 150 d.
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