期刊
MAGNETIC RESONANCE IN MEDICINE
卷 57, 期 3, 页码 554-567出版社
WILEY
DOI: 10.1002/mrm.21174
关键词
bone; MRI; WASPI; ultrashort T-2 imaging; solid-state MR imaging
资金
- NCRR NIH HHS [S10-RR16811, P41-RR14075] Funding Source: Medline
- NIA NIH HHS [R01-AG014701] Funding Source: Medline
- NIBIB NIH HHS [R01-EB004012] Funding Source: Medline
Investigators often study rats by mu CT to investigate the pathogenesis and treatment of skeletal disorders in humans. However, mu CT measurements provide information only on bone mineral content and not the solid matrix. CT scans are often carried out on cancellous bone, which contains a significant volume of marrow cells, stroma, water, and fat, and thus the apparent bone mineral density (BMD) does not reflect the mineral density within the matrix, where the mineral crystals are localized. Water- and fat-suppressed solid-state proton projection imaging (WASPI) was utilized in this study to image the solid matrix content (collagen, tightly bound water, and other immobile molecules) of rat femur specimens, and meet the challenges of small sample size and demanding submillimeter resolution. A method is introduced to recover the central region of k-space, which is always lost in the receiver dead time when free induction decays (FIDs) are acquired. With this approach, points near the k-space origin are sampled under a small number of radial projections at reduced gradient strength. The typical scan time for the current WASPI experiments was 2 hr. Proton solid-matrix images of rat femurs with 0.4-mm resolution and 12-mm field of view (FOV) were obtained. This method provides a noninvasive means of studying bone matrix in small animals.
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