期刊
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
卷 45, 期 2, 页码 116-122出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.bjoms.2006.04.012
关键词
oral squamous cell carcinoma; human papillomavirus-16; 5-year survival; clinical correlates; multivariate analysis
We examined 66 oral squamous cell carcinomas (OSCCs) for human papillomavirus-16 (HPV-16) infection to evaluate its prognostic significance. Cox regression analysis of 5-year survival demonstrated that patients without nodal metastasis or with intratumoural HPV-16 showed better prognoses compared with each counterpart. In Kaplan-Meier survival analysis, nodal status but not HPV-16 status was statistically significant. The 5-year survival rate of HPV-16 positive patients without nodal metastasis (94%) was extremely high, compared with that of HPV-16 negative patients with nodal metastasis (25%). These results suggest that HPV-16 status as well as nodal status may provide prognostic significance in patients with OSCC. (C) 2006 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
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