Body mass index - A marker for significant colorectal neoplasia in a screening population

Background and Aims: Although some studies suggest a positive association between increasing body mass index (BMI) and risk for colorectal neoplasia, the impact on screening has not been examined. We performed a cross-sectional study to examine the association of BMI and colorectal neoplasia in a screening population. Methods: Data collected for 2493 patients presenting for screening colonoscopy included known risk factors for colorectal neoplasia, demographic information, and lifestyle factors. Our outcome was the endoscopic detection of significant colorectal neoplasia which included adenocarcinoma, high-grade dysplasia, villous tissue, adenomas I cm or greater and multiple ( > 2) adenomas of any size. Results: Overall, we observed an increased risk and prevalence for significant colorectal neoplasia in women as BMI increased (P value for trend < 0.002). This relationship was the strongest for the women with a BMI >= 40 (odds ratios = 4.26; 95% confidence intervals = 2.00-9.11). There was no such relationship in our male population. Conclusions: Increasing BMI, in our population, was associated with an increase risk for colorectal neoplasia in female patients. This study reinforces the importance of screening colonoscopy especially in obese women.