期刊
EARLY HUMAN DEVELOPMENT
卷 83, 期 3, 页码 149-156出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.earlhumdev.2007.01.004
关键词
group B streptococcal infection; systematic review; meta-analysis; natural history
资金
- National Institute for Health Research [04/51/01] Funding Source: researchfish
Clinicians need information on the risk of Early Onset Group B Streptococcal disease (EOGBS) for counselling pregnant women and to decide who would benefit most from antibiotic treatment during tabour. We carried out a systematic review of the research literature and conducted meta-analyses to obtain estimates for the natural history of EOGBS that are representative of the UK population. The mean rate of colonisation for the UK was 14% and we found weak evidence that the prevalence is increasing over time. Maternal GBS colonisation was more likely in women who delivered preterm compared with at term. Just over one-third of babies born to colonised mothers become colonised with GBS at birth (36%), and 3% of cotonised babies develop EOGBS bacteraemia. In the UK, EOGBS constitutes one-third of all early onset bacteraemia due to pathogens, in contrast to one-half in the USA. (c) 2007 Elsevier Ireland Ltd. ALL rights reserved.
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