期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 101, 期 3, 页码 444-451出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2006.11.007
关键词
DNA complex interaction; chemical nucleases; copper(II) complexes
New copper(H) complexes with sulfonamide ligands have been prepared and characterized. Sulfonamide ligands were prepared through a reaction between 8-aminoquinoline and either 2-mesitylene (Hqmesa), 4-tert-butylbenzene (Hqtbsa), or alpha-toluene (H alpha qtsa) sulfonyl chlorides. The structural analysis carried out for complex [Cu(alpha qtsa)(2)] indicated that the local environment of the Cu(II) cation is between a square planar and a tetrahedral geometry, with stacking of the benzene rings of the sulfonyl ligands between neighbor molecules. Powder EPR spectra at room temperature gave rhombic spectra for the [Cu(alpha qtsa)(2)] and [Cu(qmesa)(2)] complexes and an axial spectrum for the [Cu(qtbsa)(2)] complex, probably due to the steric hindrance of the methyl groups. Complexes [Cu(alpha qtsa)(2)] and [Cu(qmesa)(2)] are artificial chemical nucleases that degrade DNA in the presence of sodium ascorbate. A study of the radical scavengers revealed that the ROS (reactive oxygen species) involved in the DNA damage were hydroxyl, singlet oxygen-like species, and superoxide anion. (c) 2006 Elsevier Inc. All rights reserved.
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