期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 331, 期 2, 页码 186-189出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2006.11.018
关键词
long-circulating liposomes; pharmacokinetics; poly(amino acid)-coatings; enzymatic degradability; complement activation
Poly(amino acid)s (PAAs) were evaluated as coating polymers for long-circulating liposomes. The pharmacokinetics of PAA-coated liposomes were assessed in rats. Prolonged circulation times were obtained, comparable to those reported for poly(ethylene glycol) (PEG)-liposomes. Besides, the enzymatic degradability of PAAs was studied. PAAs - in free as well as liposome-associated form - are degradable by proteases, which is beneficial for reducing the risks of accumulation in vivo. Furthermore, complement activation by PAA-liposomes was evaluated in vitro and in vivo. Like other liposome types, they appear to activate the complement system. However, a role of endotoxin contamination of the PAA-liposome formulations used cannot be excluded in our complement activation studies. (c) 2006 Elsevier B.V All rights reserved.
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