期刊
HEART RHYTHM
卷 4, 期 3, 页码 S17-S23出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.hrthm.2006.12.021
关键词
thoracic veins; afterdepolarizations; action potentials; ablation; arrhythmias
资金
- NHLBI NIH HHS [R01 HL058860, R01 HL066140, HL58860, HL66140] Funding Source: Medline
In 1999, Haissaguerre et al. published a landmark article showing that atrial fibrillation can be initiated by electrical activity in the pulmonary veins. Not only does it appear that electrical activity in the veins initiates fibrillation, but it also may be responsible for perpetuating fibrillation. Subsequently, similar evidence has suggested that other thoracic veins (vena cavae, coronary sinus, ligament of Marshall) initiate and perpetuate atrial, fibrillation. How does electrical impulse initiation occur in the veins? The results of numerous in vivo and in vitro studies on this subject have not conclusively defined a mechanism. Impulse initiation by automaticity and triggered activity as well as impulse initiation resulting from reentry have been suggested. In this article, we focus only on those data suggesting the possibility that triggered activity initiates and/or perpetuates atrial fibrillation.
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