Nucleic acids with a six-membered carbohydrate mimic and RNA interference

Cyclohexenyl nucteic acids and altritol nucleic acids were evaluated as RNA modifications in an siRNA experiment targeting the P-glycoprotein expression. Both modified oligonucleotides are well accepted as RNA mimics leading to an increase in potency and duration of action of the gene-silencing effect. (c) 2006 Elsevier Inc. All rights reserved.