期刊
JOURNAL OF AUTOIMMUNITY
卷 28, 期 2-3, 页码 85-98出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jaut.2007.02.006
关键词
immunoregulation; organ specific autoimmunity; genetics; autoimmune thyroiditis
类别
资金
- NIDDK NIH HHS [R01 DK061659, R01 DK061659-06, R01 DK073681, R01 DK067555, R01 DK067555-03, R01 DK073681-02] Funding Source: Medline
Autoimmune thyroid diseases (AITD) are common autoimmune diseases, affecting up to 5% of the general population. Thyroid-directed autommunity is manifested in two classical autoimmune conditions, Hashimoto's thyroiditis, resulting in hypothyroidism and Graves' disease resulting in hyperthyroidism. Autoimmune thyroid diseases arise due to an interplay between environmental and genetic factors. In the past decade significant progress has been made in our understanding of the genetic contribution to the etiology of AITD. Indeed, several AITD susceptibility genes have been identified. Some of these susceptibility genes are specific to either Graves' disease or Hashimoto's thyroiditis, while others confer susceptibility to both conditions. Both immunoregulatory genes and thyroid specific genes contribute to the pathogenesis of AITD. The time is now ripe to examine the mechanistic basis for the contribution of genetic factors to the etiology of AITD. In this review, we will focus on the contribution of non-MHC II genes. (C) 2007 Elsevier Ltd. All rights reserved.
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