期刊
NEUROTOXICOLOGY
卷 28, 期 2, 页码 290-297出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.neuro.2006.08.002
关键词
Mn; cohort study; neuropsychiatric symptoms; BSI; depression; anxiety; hostility; exposure-effect
Introduction: Psychiatric manifestations have been reported in cases of manganism, and mood disorders are often observed in manganese (Mn) exposed workers. We examined neuropsychiatric symptoms among formerly Mn-exposed workers 14 years after cessation of exposure. Materials and methods: A study was conducted in 1990 among workers from a ferro- and silico-Mn plant and unexposed working men referents from the same region in South-West Quebec. At follow-up in 2004, 77 former Mn-workers and 81 referents agreed to participate and responded to a neuropsychiatric symptom checklist, the Brief Symptom Inventory (BSI); scores were transformed into T-scores based on a normative population. Cumulated exposure indices (CEI) were computed for each former Mn-worker. Linear and logistic regression analyses were used. Results: Mean T-scores were significantly higher among former Mn-workers than referents on scales of Depression and Anxiety. Mean T-scores of psychological distress increased with the CEI tertiles, with significant associations for the scales Somatization, Depression, Anxiety and Hostility. Former Mn-workers in the two highest tertiles of CEI showed a higher risk for T-scores >= 63 for Hostility (OR, 7.5; 95% CI 1.5-38.9), Depression (OR, 2.6; 95 % CI, 1. 1-8.4) and Anxiety (OR, 3.0; 95 % CI, 1. 1-8.4). Conclusion: These results suggest that past exposure to Mn may have lasting consequences on neuropsychiatric symptoms. (c) 2006 Published by Elsevier Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据