期刊
SCIENCE
卷 315, 期 5816, 页码 1262-1266出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1137450
关键词
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资金
- Medical Research Council [G0400627, MC_U138135973, G0600368, G116/147, G0501424] Funding Source: researchfish
- MRC [G116/147, MC_U138135973, G0600368, G0400627, G0501424] Funding Source: UKRI
- Medical Research Council [MC_U138135973, G0400627(76527), G0400627, G116/147, G0501424, G0600368(77987), G0600368, G0400627(71256)] Funding Source: Medline
- Wellcome Trust [071179] Funding Source: Medline
Long-term potentiation (LTP), which approximates Hebb's postulate of associative learning, typically requires depolarization-dependent glutamate receptors of the NMDA (N-methyl-D-aspartate) subtype. However, in some neurons, LTP depends instead on calcium-permeable AMPA-type receptors. This is paradoxical because intracellular polyamines block such receptors during depolarization. We report that LTP at synapses on hippocampal interneurons mediating feedback inhibition is anti-Hebbian: It is induced by presynaptic activity but prevented by postsynaptic depolarization. Anti-Hebbian LTP may occur in interneurons that are silent during periods of intense pyramidal cell firing, such as sharp waves, and lead to their altered activation during theta activity.
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