期刊
SCIENCE
卷 315, 期 5816, 页码 1243-1249出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1136281
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The rostral migratory stream (RMS) is the main pathway by which newly born subventricular zone cells reach the olfactory bulb ( OB) in rodents. However, the RMS in the adult human brain has been elusive. We demonstrate the presence of a human RMS, which is unexpectedly organized around a lateral ventricular extension reaching the OB, and illustrate the neuroblasts in it. The RMS ensheathing the lateral olfactory ventricular extension, as seen by magnetic resonance imaging, cell-specific markers, and electron microscopy, contains progenitor cells with migratory characteristics and cells that incorporate 5-bromo-2'-deoxyuridine and become mature neurons in the OB.
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