期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 104, 期 10, 页码 3984-3989出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0700191104
关键词
alpha-galactosylceramide; B cell memory; protein vaccination; serological memory
Invariant natural killer T (iNKT) cells are innate-like lymphocytes recognizing CDid-restricted glycolipid antigens, such as alpha-galactosylceramide (alpha GC). We assessed whether iNKT cells help B lymphocyte responses and found that mice immunized with proteins and aGC develop antibody titers 1-2 logs higher than those induced by proteins alone. Activation of iNKT cells enhances protection against infections such as influenza and elicits higher frequencies of memory B cells and higher antibody responses to booster immunizations. Protein vaccination with alpha GC, but not with conventional adjuvants, elicits IgG responses in mice lacking MHC class 11 molecules, demonstrating that iNKT cells can substitute for CD4(+) T cell help to B cells. Interestingly, the decay of circulating antibodies is faster in mice lacking iNKT cells. These findings point to a homeostatic role for iNKT cells on critical features of the antibody response such as immunity and B cell memory.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据