Gd-loaded liposomes as T1, susceptibility, and CEST agents, all in one

Gd-loaded nonspherical liposomes represent a new family of MRI agents that show contrast-enhancing ability upon applying different image acquisition modes. In fact they can act either as T-1- or T-2- or CEST-agents. For the first time a Gd complex is endowed with detectable shift reagent properties.