期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 129, 期 10, 页码 2774-+出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja070071z
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资金
- NIGMS NIH HHS [R01 GM63167] Funding Source: Medline
A total synthesis of the antifungal agent papulacandin D is reported. The molecule is representative of a large class of C-aryl glycosides that exhibit significant antifungal activity. The synthetic strategy bifurcates the molecule into two nearly equal subunits, the arylglycoside and 18-carbon fatty acid side chain. The key strategic transformations are (1) the palladium catalyzed, organosilanolate-based cross-coupling of a protected glucal silanol and (2) a catalytic enantioselective allylation of a dienal using allyltrichlorosilane. The synthesis was accomplished in 31 steps overall from commercial starting materials to afford over 50 mg of the natural product.
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