期刊
VIROLOGY
卷 359, 期 2, 页码 425-435出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2006.09.044
关键词
KSHV; interleukin 6; IL-6; vIL-6; Kaposi's sarcoma
类别
资金
- NCI NIH HHS [R01 CA097934-01A1, R01 CA097934, R01 CA097934-04] Funding Source: Medline
- NIAID NIH HHS [P30 AI027757] Funding Source: Medline
Kaposi's Sarcoma-associated herpesvirus encodes a homolog of the human cellular interleukin-6 that may play a formative role in many KSHV-related diseases. While the viral IL-6 can signal similarly to its human counterpart little is known about the role of vIL-6 during KSHV infection. Using homologous recombination and selection in eukaryotic cells, a KSHV isolate was purified that does not express vIL-6 as was a control recombinant that left vIL-6 intact. The two viruses establish and maintain latency to similar levels in BJAB B-cells, reactivate to similar levels in B-cells and Monkey kidney cells and have very similar KSHV gene expression patterns. BJAB cells expressing KSHV survive better than the parental BJAB cells in low serum and the vIL-6 deletion does not abrogate this growth advantage. Thus vIL-6 is not essential for establishment, maintenance, or reactivation from latency in cell culture and is not involved in the survival of infected BJAB B-cells in low serum. (c) 2006 Elsevier Inc. All rights reserved.
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