Formation of chiral quaternary carbon stereocenters using silylene transfer reactions:: Enantioselective synthesis of (+)-5-epi-acetomycin

Chiral quaternary carbon stereocenters can be established with high diastereoselectivity by a silylene transfer/Ireland-Claisen rearrangement. The utility of this method was demonstrated by application to a synthesis of (+)-5-epi-acetomycin.