期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 17, 期 6, 页码 1579-1583出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.12.101
关键词
taxoids; 2-deacetoxytaxinine J; multidrug resistance (MDR)
A small library of 2-deacetoxytaxinine J (DAT-J) 1 derivatives was synthesised and tested in vitro for their reversal activity in human mammary carcinoma MDR cell line MCF7-R. One of the new taxoids showed to be active at 0. 1 mu M when tested in combination with paclitaxel. (c) 2007 Elsevier Ltd. All rights reserved.
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