期刊
BRAIN RESEARCH BULLETIN
卷 71, 期 5, 页码 493-500出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2006.11.002
关键词
repetitive transcranial magnetic stimulation; morris water maze test; reference memory; working memory
Repetitive transcranial magnetic stimulation (rTMS) is a novel, non-invasive neurological and psychiatric tool. The low-frequency (1Hz or less) rTMS is likely to play a particular role in its mechanism of action with different effects in comparison with high-frequency (> 1 Hz) rTMS. There is limited information regarding the effect of low-frequency rTMS on spatial memory. In our study. each male Wistar rat was daily given 300 stimuli (1.0 T 200 mu s) at a rate of 0.5 Hz or sham stimulation. We investigated the effects of chronic and acute rTMS on reference/working memory process in Morris water maze test with the hypothesis that the effect would differ by chronic or acute condition. Chronic low-frequency rTMS impaired the retrieval of spatial short- and long-term spatial reference memory but not acquisition process and working memory, whereas acute low-frequency rTMS predominantly induced no deficits in acquisition or short-term spatial reference memory as well as working memory except for long-term reference memory. In summary, chronic 0.5 Hz rTMS disrupts spatial short- and long-term reference memory function. but acute rTMS differently affects reference memory. Chronic low-frequency rTMS may be used to modulate reference memory. Treatment protocols using low-frequericy rTMS in neurological and psychiatric disorders need to take into account the potential effect of chronic low-frequency rTMS on memory and other cognitive functions. (c) 2006 Elsevier Inc. All rights reserved.
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