期刊
BIOSENSORS & BIOELECTRONICS
卷 22, 期 8, 页码 1723-1732出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2006.08.011
关键词
biocompatibility; conducting polymer; neural interface; neural prosthesis; self-assembled monolayer
There is continued interest in the development of conductive polymer coatings to improve the electrical properties and biocompatibility of electrodes for neural prostheses. We present here a new type of coating, based on mixed self-assembled monolayers (SAMs) of thiolated poly(alkylthiophene)s and functionalized alkanethiols. When assembled as a SAM on electrodes designed for in vitro electrophysiology, these polymers are able to significantly lower electrode impedance at 1 kHz. The same mixed formulation is able to promote the outgrowth of neurites from primary mouse cortical neurons when the alkanethiol component is functionalized with a neural cell adhesion molecule (NCAM) binding antibody. Atomic force microscopy of the SAMs shows that they exert their effect through the well-known mechanism of increasing electrode surface area. These new covalently bound films have the potential to be more robust and are more controllable in their composition than existing electrodeposited conductive polymer coatings. Published by Elsevier B.V.
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