期刊
TETRAHEDRON LETTERS
卷 48, 期 12, 页码 2213-2216出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2007.01.061
关键词
imidazo[1,2-c]pyrimidiiies; [4+1]-cyloaddition; combinatorial chemistry; three component condensation (3CC)
A new and versatile synthesis of imidazo[1,2-c]pyrimidines via a [4+1]-cycloaddition is described. The reported novel synthetic approach leads to pharmacologically interesting scaffolds containing three points of potential diversity, which previously were not accessible under conventional conditions. In addition, this novel synthetic procedure is amenable to the assembly of libraries with this interesting core structure. (c) 2007 Elsevier Ltd. All rights reserved.
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