期刊
VIROLOGY
卷 360, 期 1, 页码 72-83出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2006.09.049
关键词
measles virus; phosphoprotein; innate immunity; interferon signaling
类别
资金
- NIAID NIH HHS [R01 AI 63476, R01 AI 57761] Funding Source: Medline
The measles virus (MV) P gene encodes three proteins: P, an essential polymerase cofactor, and C and V, which have multiple functions including immune evasion. We show here that the MV P protein also contributes to immune evasion, and that tyrosine 110 is required to block nuclear translocation of the signal transducer and activator of transcription factors (STAT) after interferon type I treatment. In particular, MV P inhibits STAT1 phosphorylation. This is shown not only by transient expression but also by reverse genetic analyses based on a new functional infectious cDNA derived from a MV vaccine vial (Moraten strain). Our study also identifies a conserved sequence around P protein tyrosine I 10 as a candidate interaction site with a cellular protein. (c) 2006 Elsevier Inc. All rights reserved.
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