Asymmetric Michael reaction:: novel efficient access to chiral β-ketophosphonates

The asymmetric Michael reaction between chiral beta-enaminophosphonates derived from (S)-1-phenylethylamine and various electrophilic alkenes furnished beta,beta-disubstituted ketophosphonates in good yields and with excellent enantioselectivity. (c) 2007 Elsevier Ltd. All rights reserved.