Tetrahydroquinoline and tetrahydroisoquinoline mixed ligand rhenium complexes with the SNS/S donor atom set

New oxorhenium complexes with 3-methylazapentane-1,5-dithiolate (SNMeS) and thiol functionalized monodentate tetrahydroquinolyl and tetrahydroisoquinolyl derivatives have been synthesized by simultaneous reaction of [PPh3](2)[Re(O)Cl-3] with tridentate HSNMeSH and the corresponding N-heterocycle containing thiol. The characterization of complexes involved elemental analysis, IR, H-1 and C-13 NMR spectroscopy and X-ray crystallographic analysis. The nature of the heterocycle in monodentate ligand, even situated at the distance of two methylene group length, has been found to have a significant influence on the molecular conformation. Metal complexes were found to be active in psychotropic in vivo and cytotoxicity in vitro screening. Copyright (c) 2007 John Wiley & Sons, Ltd.