期刊
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
卷 37, 期 4, 页码 738-747出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10803-006-0205-z
关键词
fragile X syndrome (FXS); fragile X premutation (FXP); Autism Spectrum Disorder (ASD); Autism Diagnostic Observation Schedule-Generic (ADOS-G) Autism Diagnostic Interview-Revised (ADI-R)
资金
- NCRR NIH HHS [5M01RR00069] Funding Source: Medline
- NICHD NIH HHS [HD36071] Funding Source: Medline
The behavioural phenotype of autism was assessed in individuals with full mutation and premutation fragile X syndrome (FXS) using the Autism Diagnostic Observation Scale-Generic (ADOS-G) and the Autism Diagnostic Interview (ADI-R). The participants, aged 5-80 years, comprised 33 males and 31 females with full mutation, 7 males and 43 females with premutation, and 38 non-fragile X relatives (29 males, 9 females). In the full mutation group, a total of 67% males and 23% females met either the Autism Disorder (AD) or the Autism Spectrum Disorder (ASD) criteria on at least one of the diagnostic tests. In the premutation group, 14% males and 5% females met the ADOS-G criteria for ASD. The presence of autism manifestations in males and females with full mutation and premutation provide support for a spectrum view.
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