期刊
SENSORS
卷 7, 期 4, 页码 420-437出版社
MDPI
DOI: 10.3390/s7040420
关键词
platinum-iridium electrodes; polymer electrosynthesis; cyclic voltammetry; amperometry; proteins; cyclodextrins; ascorbate; hydrogen peroxide; brain analysis
Reports that globular proteins could enhance the interference blocking ability of the PPD (poly(o-phenylenediamine) layer used as a permselective barrier in biosensor design, prompted this study where a variety of modifying agents were incorporated into PPD during its electrosynthesis on Pt-Ir electrodes. Trapped molecules, including fibrous proteins and beta-cyclodextrin, altered the polymer/modifier composite selectivity by affecting the sensitivity to both H2O2 (signal molecule in many enzyme-based biosensors) and the archetypal interference species, ascorbic acid. A comparison of electrochemical properties of Pt and a Pt-Ir alloy suggests that the benefits of the latter, more rigid, metal can be exploited in PPD-based biosensor design without significant loss of backward compatibility with studies involving pure Pt.
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