期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 37, 期 4, 页码 925-934出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/eji.200635882
关键词
adhesion; cell migration; T cells; thymopoiesis
类别
The role of CD44 in T cell biology remains incompletely understood. Although studies using anti-CD44 antibodies have implicated this cell adhesion molecule in a variety of important T cell processes, few T cell defects have been reported in CD44-deficient mice. We have assessed the requirement for CD44 in T cell development and mature T cell function by analyzing mice in which CD44(-/-) and WT cells were produced simultaneously. In mixed (CD44(-/-) + CD44(+/+),) bone marrow chimeras, production of CD44(-)/(-) T cells was shown to be reduced compared to WT cells due to inefficient intrathymic development. In addition, mature CD44(-/-) CD8(+) T cells generated a substantially lower response than WT T cells after infection of mice with lymphocytic choriomeningitis virus, with the reduction in response apparent in both lymphoid and non-lymphoid tissues. Overall, these results demonstrate a poor capacity of CD44(-/-) lineage cells to compete with WT cells at multiple levels, implicating CD44 in normal T cell function.
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