期刊
EUROPEAN JOURNAL OF CANCER
卷 43, 期 6, 页码 1101-1107出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2007.01.029
关键词
APAF-1; colorectal cancer; immunohistochemistry; tissue microarray; prognosis
类别
The aim of this study was to determine the prognostic value of APAF-1 in colorectal cancer (CRC). Immunohistochemistry for APAF-1 was performed on a tissue microarray of 1015 mismatch-repair (MMR) proficient and 130 sporadic MLH1-negative CRCs. The association of APAF-1 with clinico-pathological features including 10-year survival time was analysed. Methylation specific PCR was performed on a subset of MMR-proficient and MLH1-negative CRC. Loss of APAF-1 was associated with advanced T stage (p-value = 0.022), N stage (p-value = 0.009), vascular invasion (p-value = 0.001) and worse survival (P-value = 0.017) in MMR-proficient CRC. In MLH1-negative CRC, loss of APAF-1 was associated with metastasis (p-value=0.041), worse prognosis (p-value < 0.001) and independently predicted shorter survival time (p-value < 0.001). No methylation was found in the selected region of APAF-1. APAF-1 is a marker of tumour progression in MMR-proficient CRC and an independent adverse prognostic factor in MLH1-negative CRC. (C) 2007 Elsevier Ltd. All rights reserved.
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