期刊
JOURNAL OF APPLIED PHYSIOLOGY
卷 102, 期 4, 页码 1702-1707出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.00722.2006
关键词
oxidant stress; heat shock proteins; antioxidant
Skeletal muscle reloading following disuse is characterized by profound oxidative damage. This study tested the hypothesis that intermittent hyperthermia during reloading attenuates oxidative damage and augments skeletal muscle regrowth following immobilization. Forty animals were randomly divided into four groups: control (Con), immobilized (Im), reloaded (RC), and reloaded and heated (RH). All groups but Con were immobilized for 7 days. Animals in the RC and RH groups were then reloaded for 7 days with (RH) or without (RC) hyperthermia (41-41.5 degrees C for 30 min on alternating days) during reloading. Heating resulted in similar to 25% elevation in heat shock protein expression (P < 0.05) and an similar to 30% greater soleus regrowth (P < 0.05) in RH compared with RC. Furthermore oxidant damage was lower in the RH group compared with R because nitrotyrosine and 4-hydroxy-2-nonenol were returned to near baseline when heating was combined with reloading. Reduced oxidant damage was independent of antioxidant enzymes (manganese superoxide dismutase, copper-zinc superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase). In summary, these data suggest that intermittent hyperthermia during reloading attenuates oxidative stress and improves the rate of skeletal muscle regrowth during reloading after immobilization.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据