期刊
JOURNAL OF NEURO-ONCOLOGY
卷 82, 期 2, 页码 125-131出版社
SPRINGER
DOI: 10.1007/s11060-006-9262-6
关键词
differential display; gene; malignant astrocytoma cell lines; motile ability
The most characteristic feature of a malignant astrocytoma is its early and extensive infiltration into adjacent parenchymal structures. We focused on detecting the possible expression changes as the determining factors for malignant astrocytoma's motile ability. We confirmed that four of 39 genes showed different expression on DD-PCR by RT-PCR and Northern blot analysis. These findings suggest that the genes identified may be important for determining high motility in astrocytoma cell lines. These findings may help us understand the molecular invasion mechanism in astrocytomas.
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