期刊
NATURE NEUROSCIENCE
卷 10, 期 4, 页码 485-493出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1859
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资金
- NIH HHS [5-DPI-OD114-02] Funding Source: Medline
- PHS HHS [58754] Funding Source: Medline
Memories maintained in patterns of synaptic connectivity are rapidly overwritten and destroyed by ongoing plasticity related to the storage of new memories. Short memory lifetimes arise from the bounds that must be imposed on synaptic efficacy in any realistic model. We explored whether memory performance can be improved by allowing synapses to traverse a large number of states before reaching their bounds, or by changing the way these bounds are imposed. In the case of hard bounds, memory lifetimes grow proportional to the square of the number of synaptic states, but only if potentiation and depression are precisely balanced. Improved performance can be obtained without fine tuning by imposing soft bounds, but this improvement is only linear with respect to the number of synaptic states. We explored several other possibilities and conclude that improving memory performance requires a more radical modification of the standard model of memory storage.
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