期刊
AMYOTROPHIC LATERAL SCLEROSIS
卷 8, 期 2, 页码 101-105出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/17482960601029883
关键词
amyotrophic lateral sclerosis; apnoea; respiratory function; nocturnal oximetry; diaphragm
There are a number of sleep studies in amyotrophic lateral sclerosis (ALS), in general including a heterogeneous population of patients. We aimed to study sleep in a population of selected ALS patients by investigating nocturnal polysomnography (PSG) characteristics in ALS patients with normal respiratory function tests and preserved diaphragmatic innervation. Ninety-two ALS patients were screened by percutaneous nocturnal oximetry (PNO). Eleven ALS patients with normal respiratory function tests, phrenic motor responses and preserved motor units on needle electromyography of the diaphragm, but abnormal PNO, were selected for PSG. REM was present in eight patients, but normal in only three. Three patients had mixed apnoea-hypopnoea, severe in one. Seven showed a pattern of periodic mild O-2 desaturation, which occurred in REM (3), REM and NREM (3) and in NREM sleep (1). One patient studied six months later had more severe changes in the second evaluation. In conclusion, the most common sleep disordered breathing was periodic mild O-2 desaturation independent of the sleep stage (REM, NREM). This might represent central drive dysfunction or respiratory muscle fatigue in ALS.
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