期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 14, 期 4, 页码 344-346出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb1217
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资金
- NCI NIH HHS [CA089455] Funding Source: Medline
- NIGMS NIH HHS [GM61204, GM069905] Funding Source: Medline
Histone H3 Lys4 (H3K4) is methylated by yeast Set1-COMPASS and its mammalian homolog, the MLL complex. Human JARID1d can demethylate trimethyl-H3K4 (H3K4me3). We identified Drosophila melanogaster little imaginal discs (Lid) as the JARID1d homolog. We report that Lid knockdown using RNA interference results in a specific genome-wide increase in H3K4me3 levels without affecting other patterns of H3 methylation, and results in an altered distribution of the chromo-helicase protein Chd1.
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