期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 45, 期 4, 页码 656-661出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2006.10.022
关键词
Passiflora alata; antioxidant; carbon tetrachloride
The leaf extract of Passiflora alata Dryander (P. alata) has been demonstrated to possess antioxidant activity in vitro. The aim of this study was to investigate the effects of P. alata leaf extract pretreatment on carbon tetrachloride-treated rats. Male Wistar rats were randomly allocated into four groups: group 1 (control - vehicle), group 2 and 3 (P. alata extract - 1 and 5 mg/kg, respectively) and group 4 (trolox - 0.18 mg/kg). Rats received daily pretreatment by oral gavage for 30 days followed by a single dose of CCl4 (3 ml/kg i.p. in vegetable oil) on the 30th day and were killed after 6 h. The pretreatment with the P. alata extract provided significant protection to liver, evidenced by lower degree of necrosis, decreased lipid peroxidation (TBARS) and higher catalase and superoxide dismutase activities. Additionally, pretreated-rats with P. alata (5 mg/kg) showed significantly decreased cardiac TBARS levels. Our results indicate that a low oral dose of P. alata leaf extract has both hepato and cardioprotective effects on rats treated with CCl4. (c) 2006 Elsevier Ltd. All rights reserved.
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