期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 14, 期 4, 页码 341-343出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb1216
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资金
- NCI NIH HHS [P30 CA08748] Funding Source: Medline
- NIGMS NIH HHS [GM68804, GM46567] Funding Source: Medline
Recent studies have demonstrated that histone methylation can be dynamically regulated through active demethylation. However, no demethylase specific to histone H3 trimethyl-Lys4 (H3K4me3) has been identified. Here we report that the Drosophila melanogaster protein 'little imaginal discs' (Lid), a JmjC domain-containing trithorax group protein, can demethylate H3K4me3. Consistent with its genetic classification, Lid positively regulates Hox gene expression in S2 cells.
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