期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 17, 期 7, 页码 1979-1983出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.01.021
关键词
antifungal; strobulirin natural products; beta-methoxylacrylates; click chemistry
A library of potential antifungal triazole-modified P-methoxyacrylate analogues was designed and synthesized via a Cu(I)-catalyzed 1,3-dipolar alkyne-azide coupling reaction or 'click chemistry'. Subsequent biological screening revealed that some compounds displayed low to moderate antifungal activity toward pathogenic fungi and low phytotoxicity. (c) 2007 Elsevier Ltd. All rights reserved.
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