期刊
JOURNAL OF DENTAL RESEARCH
卷 86, 期 4, 页码 378-383出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/154405910708600415
关键词
dental composite; nano-particles; whisker reinforcement; tooth caries inhibition; Ca and PO4 ion release
资金
- NIDCR NIH HHS [R01 DE014190, R01 DE14190, R01 DE017974, R01 DE017974-01A2, R01 DE014190-06] Funding Source: Medline
Nano-particles of dicalcium phosphate anhydrous ( DCPA) were synthesized for the first time. The objectives of this study were to incorporate DCPA nano-particles into resin for Ca-PO4 release to combat dental caries, and to investigate the filler level effects. Nano-DCPA and nano-silica-fused silicon nitride whiskers at a 1:1 ratio were used at filler mass fractions of 0-75%. The flexural strengths in MPa (mean +/- SD; n = 6) of DCPA-whisker composites ranged from (106 +/- 39) at 0% fillers to (114 +/- 23) at 75% fillers, similar to (112 +/- 22) of a non-releasing composite (TPH) (p > 0.1). The composite with 75% fillers in a NaCl solution (133 mmol/L, pH = 7.4, 37 degrees C) yielded a Ca concentration of (0.65 +/- 0.02) mmol/L and PO4 of (2.29 +/- 0.07) mmol/L. Relationships were established between ion-release and DCPA volume fraction V-DCPA: Ca = 4.46 V-DCPA(1.6), and PO4 = 66.9 V-DCPA(2.6). Nano-DCPA-whisker composites had high strength and released high levels of Ca-PO4 requisite for remineralization. These new nano-composites could provide the needed combination of stress-bearing and caries-inhibiting capabilities.
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