期刊
CANCER GENE THERAPY
卷 14, 期 4, 页码 364-371出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.cgt.7701018
关键词
dendritic cell; Flt3L; mammary tumor; breast cancer; cytokine
Dendritic cell (DC) expansion is regulated by the hematopoietic growth factor fms-like tyrosine kinase 3 ligand (Flt3L). DCs are critical to the control of tumor growth and metastasis, and there is a positive correlation between intratumoral DC infiltration and clinical outcome. In this report, we first demonstrate that single intravenous (i.v.) injections of adenovirus (Adv)-Flt3L significantly increased splenic dendritic, B, T and natural killer (NK) cell numbers in both normal and mammary tumor-bearing mice. In contrast, the numbers of DCs and T cells infiltrating the tumors were not increased. Consistent with the minimal effect on immune cell infiltration, i.v. Adv-Flt3L injections had no therapeutic activity against orthotopic mammary tumors. In addition, we noted tumor and Adv-Flt3L expansion of Gr1(+)CD11b(+) immature myeloid suppressor cells (IMSCs), which may inhibit the therapeutic efficacy of Adv-Flt3L-expanded DCs. Cancer Gene Therapy (2007) 14, 364-371. doi: 10.1038/sj.cgt. 7701018; published online 19 January 2007.
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