期刊
THERAPEUTIC DRUG MONITORING
卷 29, 期 2, 页码 171-176出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/FTD.0b013e31803bb54e
关键词
saquinavir; pregnancy; pharmacokinetics; therapeutic drug monitoring; antiretroviral treatment
The efficacy of low-dose, ritonavir-boosted saquinavir (SQV/rtv) once daily plus 2 nucleoside retrotranscriptase inhibitors (NRTIs)inpregnanthuman innoLmodeficiency virus (HIV)-1-infected women was prospectively evaluated, ensuring a SQV minimum concentration (C-min) >= 100 ng/mL with a therapeutic drug monitoring strategy. The primary clinical endpoint was the percentage of women with an HIV-RNA viral load (VL) of < 50 copies/mL at the time of delivery. Forty-nine pregnancy episodes were included, with a median CD4 Count and VL of 441/mu L and 3710 copies/mL, respectively. Two patients were lost to follow-up and I patient discontinued treatment because of abdominal discomfort. SQV levels were in excess of the target C-min, in 43 of 46 episodes (93.4%) in which the end of pregnancy was reached on 1200/100 mg daily. The dosage was increased to 1600/100 mg in the remaining 3 episodes to achieve the target levels. By an intention-to-treat analysis, VL was undetectable at delivery in 43 episodes (87.7%; 95% confidence interval, 78.5-96.9) after a median of 18 weeks of treatment (range, 3-39). In the 3 episodes remaining, VLs of 110,400 copies/inL and no available data were observed after only 3 weeks of treatment. Mild adverse events attributable to SQV/rtv occurred in 6 of 49 pregnancies (12.2%). No cases of HIV vertical transmission were observed. The pharmacokinetics, efficacy, and tolerability of this regimen suggest that once-daily low-dose boosted SQV may be considered an appropriate option in PI-naive or limited-PI-experienced HIV-infected pregnant women. Nevertheless, therapeutic drug monitoring is advisable to maintain appropriate levels throughout pregnancy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据