期刊
BIOMATERIALS
卷 28, 期 10, 页码 1778-1786出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2006.12.012
关键词
inflammation; hydrogel; cytokine; drug release; adhesion
资金
- NIGMS NIH HHS [GM073626] Funding Source: Medline
Postoperative peritoneal adhesions cause pelvic pain, infertility, and potentially lethal bowel obstruction. We have designed and synthesized an injectable hydrogel composed of cross-linkable modified hyaluronic acids (HAs) conjugated to dexamethasone (HAX-DEX), and investigated its anti-inflammatory function. HAX-DEX formed a hydrogel in < 1 min by cross-linking reactions between aldehyde groups and hydrazide groups. The hydrogel degraded in media over 5 days, releasing dexamethasone slowly over that time, reducing TNF-alpha and IL-6 production from lipopolysaccharide-stimulated primary mouse macrophages in vitro. HAX-DEX was biocompatible on subcutaneous injection, and caused less inflammation than unmodified cross-linked HA. (c) 2006 Elsevier Ltd. All rights reserved.
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