期刊
NEUROCHEMISTRY INTERNATIONAL
卷 50, 期 5, 页码 719-725出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2007.01.007
关键词
mitochondria; mitochondrial membrane potential; cardiolipin; electron transport chain; lipid peroxidation; brain aging
A noticeable loss of cardiolipin, a significant accumulation of fluorescent products of lipid peroxidation and an increased ability to produce reactive oxygen species in vitro are characteristics of aged rat brain mitochondria, as has been demonstrated in this study. In contrast mitochondrial electron transport chain activity is Dot significantly compromised except a marginal decline in complex IV activity in aged rat brain. On the other hand, a striking loss of mitochondrial membrane potential occurs in brain mitochondria during aging, which may be attributed to peroxidative membrane damage in this condition. Such mitochondrial dysfunctions as reported here may lead to uncoupling of oxidative pbosphorylation, ATP depletion and activation of apoptotic cascade in aged rat brain. (c) 2007 Elsevier Ltd. All rights reserved.
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