Synthesis and antiviral activity of C-fluoro-branched cyclopropyl nucleosides

A series of novel fluorocyclopropyl nucleosides were synthesized starting from acetol using the Simmons-Smith reaction as a key reaction. All the nucleosides synthesized were assayed against several viruses. Among the compounds synthesized, the uracil analogue 22 showed moderate anti-HCMV activity (10.61 mu g/mL, in AD-169). (c) 2006 Elsevier Masson SAS. All rights reserved.