期刊
CLINICAL PHARMACOLOGY & THERAPEUTICS
卷 81, 期 4, 页码 547-556出版社
WILEY
DOI: 10.1038/sj.clpt.6100126
关键词
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资金
- NCRR NIH HHS [M01RR-00037] Funding Source: Medline
- NIBIB NIH HHS [P41 EB001975] Funding Source: Medline
- NICHD NIH HHS [5U10HD047892] Funding Source: Medline
Amoxicillin is recommended for anthrax prevention in pregnancy. The objective of this study was to evaluate the pharmacokinetics of amoxicillin during pregnancy and postpartum ( PP). Sixteen women received amoxicillin during gestation (18-22 weeks (T2) and 30-34 weeks (T3)) as well as 3 months postpartum (PP) to evaluate single-dose pharmacokinetics. Amoxicillin compartmental pharmacokinetic parameters were used to simulate amoxicillin concentration-time profiles following different dosage strategies. Amoxicillin CLrenal (T2: 24.8 +/- 6.7 l/ h, P < 0.001; T3: 24.0 +/- 3.9 l/h, P < 0.001; and PP: 15.3 +/- 2.6 l/h) and renal CLsecretion (T2: 2807105ml/ min, P < 0.002; T3: 259754 ml/min, P < 0.001; and PP: 167 +/- 47ml/min) were higher during pregnancy than postpartum. Simulations suggest that amoxicillin concentrations adequate to prevent anthrax may be difficult to achieve during pregnancy and postpartum. Increases in amoxicillin CLrenal and renal CLsecretion reflect increases in filtration and secretory transport or diminished reabsorption in the kidneys. Amoxicillin may not be an appropriate antibiotic for post-anthrax exposure prophylaxis.
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