期刊
FASEB JOURNAL
卷 21, 期 4, 页码 1107-1116出版社
FEDERATION AMER SOC EXP BIOL
DOI: 10.1096/fj.06-6802com
关键词
antimicrobial peptides; cathelicidin; complement
资金
- NIAID NIH HHS [AI-48176, AI-048694] Funding Source: Medline
Antibiotics are designed to support host defense in controlling infection. Here we describe a paradoxical inhibitory effect of bacteriostatic antibiotics on key mediators of mammalian innate immunity. When growth of species including Escherichia coli and Staphylococcus aureus is suppressed by chloramphenicol or erythromycin, the susceptibility of the bacteria to cathelicidin antimicrobial peptides or serum complement was markedly diminished. Survival of the bacteria in human whole blood, human wound fluid, or a mouse wound infection model was in turn increased after antibiotic-induced bacteriostasis. These findings provide a further rationale against the indiscriminate use of antibiotics.
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