期刊
REPRODUCTIVE TOXICOLOGY
卷 23, 期 3, 页码 383-390出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2006.10.002
关键词
bisphenol A; xenoestrogen; mammary gland; rat; carcinogenesis; carcinoma in situ
资金
- NIEHS NIH HHS [R01 ES008314-10A2, R01 ES008314-09, R21 ES012301-02, R21 ES012301, R21 ES012301-01A2, R01 ES008314, ES012301, ES08314] Funding Source: Medline
Exposure of the fetus to excess estrogen is believed to increase the risk of developing breast cancer during adult life. Fetal exposure to low doses of the xenoestrogen bisphenol A resulted in long-lasting effects in the mouse mammary gland that were manifested during adult life. It enhanced sensitivity to estradiol, decreased apoptosis, increased the number of progesterone receptor-positive epithelial cells at puberty and increased lateral branching at 4 months of age. We now report that fetal exposure to 2.5, 25, 250 and 1000 mu g bisphenol A/kg body weight/day induces the development of ductal hyperplasias and carcinoma in situ at postnatal day 50 and 95 in rats. These highly proliferative lesions have an increased number of estrogen receptor-alpha positive cells. Thus, fetal bisphenol A exposure is sufficient to induce the development of preneoplastic and neoplastic lesions in the mammary gland in the absence of any additional treatment aimed at increasing tumor development. (c) 2006 Elsevier Inc. All rights reserved.
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