期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 35, 期 -, 页码 424-427出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0350424
关键词
brain-derived neurotrophic factor (BDNF); long-term potentiation (LTP); nerve growth factor (NGF); neurodegeneration; p75 neurotrophin receptor (p75NTR); tropomyosin receptor kinase (Trk)
it is beyond doubt that the neurotrophin family of proteins plays key roles in determining the fate of the neuron, not only during embryonic development, but also in the adult brain. Neurotrophins such as NGF (nerve growth factor) and BDNF (brain-derived neurotrophic factor) can play dual roles: first, in neuronal survival and death, and, secondly, in activity-dependent plasticity. The neurotrophins manifest their effects by binding to two discrete receptor subtypes: the Trk (tropomyosin receptor kinase) family of RTKs (receptor tyrosine kinases) and the p75NTR (p75 neurotrophin receptor). The differential activation of these receptors by the mature neurotrophins and their precursors, the proneurotrophins, renders analysis of the biological functions of these receptors in the adult brain highly complex. Here, we briefly give a broad review of current knowledge of the roles of neurotrophins in the adult brain, including expression of hippocampal plasticity, neurodegeneration and exercise-induced neuroprotection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据