期刊
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
卷 57, 期 1-4, 页码 173-177出版社
SPRINGER
DOI: 10.1007/s10847-006-9200-4
关键词
inclusion complex; freeze-drying; methyl-beta-cyclodextrin; omeprazole; spray-drying
In this work, we illustrate the usefulness of cyclodextrins, namely, methyl-beta-cyclodextrin (M beta CD), an amorphous, methylated derivative of the natural beta-cyclodextrin (beta CD), as a tool to form an inclusion complex with omeprazole (OME), a poorly water soluble drug. Solid binary systems between OME and M beta CD were prepared experimentally in a stoichiometry 1:1 by different techniques (physical mixing, kneading, spray-drying and freeze-drying). Afterward these products were characterized by Fourier transformation-infrared spectroscopy (FTIR); X-ray diffractometry (XRD) and scanning electron microscopy (SEM). The results obtained suggest that spray-drying and freeze-drying methods yield a higher degree of amorphous entities suggesting the formation of inclusion complexes between OME and M beta CD.
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