期刊
ANESTHESIOLOGY
卷 121, 期 5, 页码 990-998出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/ALN.0000000000000436
关键词
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资金
- National Institutes of Health, Bethesda, Maryland [DP2-OD006454, DP1-OD003646, TR01-GM104948, T32GM007592]
- Foundation of Anesthesia Education and Research, Rochester, Minnesota
- Massachusetts General Hospital Faculty Development Award, Boston, Massachusetts
- Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts
Background: The neural mechanisms of anesthetic vapors have not been studied in depth. However, modeling and experimental studies on the intravenous anesthetic propofol indicate that potentiation of -aminobutyric acid receptors leads to a state of thalamocortical synchrony, observed as coherent frontal alpha oscillations, associated with unconsciousness. Sevoflurane, an ether derivative, also potentiates -aminobutyric acid receptors. However, in humans, sevoflurane-induced coherent frontal alpha oscillations have not been well detailed. Methods: To study the electroencephalogram dynamics induced by sevoflurane, the authors identified age- and sex-matched patients in which sevoflurane (n = 30) or propofol (n = 30) was used as the sole agent for maintenance of general anesthesia during routine surgery. The authors compared the electroencephalogram signatures of sevoflurane with that of propofol using time-varying spectral and coherence methods. Results: Sevoflurane general anesthesia is characterized by alpha oscillations with maximum power and coherence at approximately 10 Hz, (mean SD; peak power, 4.3 +/- 3.5 dB; peak coherence, 0.73 +/- 0.1). These alpha oscillations are similar to those observed during propofol general anesthesia, which also has maximum power and coherence at approximately 10 Hz (peak power, 2.1 +/- 4.3 dB; peak coherence, 0.71 +/- 0.1). However, sevoflurane also exhibited a distinct theta coherence signature (peak frequency, 4.9 +/- 0.6 Hz; peak coherence, 0.58 +/- 0.1). Slow oscillations were observed in both cases, with no significant difference in power or coherence. Conclusions: The study results indicate that sevoflurane, like propofol, induces coherent frontal alpha oscillations and slow oscillations in humans to sustain the anesthesia-induced unconscious state. These results suggest a shared molecular and systems-level mechanism for the unconscious state induced by these drugs.
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