期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 35, 期 -, 页码 267-269出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0350267
关键词
cullin-RING ubiquitin ligase; inhibitor of nuclear factor kappa B (1 kappa B); inhibitor of nuclear factor kappa B alpha kinase complex (IKK complex); NEDD8; nuclear factor kappa B (NF-kappa B); beta-transducin repeat-containing protein (beta-TrCP)
one of the important cellular factors involved in the regulation of the host antimicrobial response is the immediate early response transcription factor NF-kappa B (nuclear factor tee). Human pathogenic micro-organisms trigger cellular signal transduction pathways that induce NF-kappa B, but pathogens have also found ways to overcome the inflammatory response through active manipulation of NF-kappa B regulators. Exploration of the mechanisms that influence NF-kappa B activity could contribute to a better understanding of the molecular pathogenesis of microbial infections and could be important for potential therapeutic intervention that may be relevant in a wide variety of inflammatory diseases.
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